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  Posted at 5:03pm on Saturday, March 15th, 2008

Target Mitochondrion – Exciting New Drugs on the Horizon The Light at the End of the Tunnel Is Getting Brighter
Several recent research articles have opened up exciting new opportunities in the treatment of CLL. These feature new small molecule drugs that take an entirely different approach to targeting CLL cells. These are not your father's chemotherapy drugs, most of which target the nuclear DNA of cells, with the unavoidable risk of mutagenicity. Nor are they bulky (and expensive!) monoclonal antibodies like Rituxan and Campath, which have a hard time dealing with bulky lymph nodes and bone marrow - to some degree because it is hard for these "fat ladies" to get into all the nooks and crannies of bone marrow and lymph nodes. Small molecules like the ones we discuss below are more likely to reach all these hard-to-reach parts. Here is the best part: in this new approach to treating CLL,... read more »